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Epidemiology is a fast-developing field that covers a broad spectrum of research activities evaluating frequencies, cause-consequence relationships, and prediction pertaining to health states. As such, it serves as the cornerstone methodological domain at the intersection of clinical medicine and population/public health. In light of the ever-increasing size and dimensionality of available data (so-called “big data”), the development of new, increasingly automated analytical approaches, and the shift in paradigms due to the “causal revolution” across the last two decades, it is of utmost importance to correctly apply and actively develop suitable methods to address the pressing questions pertaining to medicine and population health that have a regional, national, or global relevance.