Desert Locust plagues can be an important contributing factor to famines and a threat to food security in many regions of the world. The Desert Locust plague of 1986–1989 and subsequent upsurges during the past two decades demonstrate the continuing capacity of this historic pest to threaten agriculture and livelihoods over large parts of Africa, the Near East and SouthWest Asia. In 2004–2005, a major upsurge caused significant crop losses in West Africa, with a negative impact on food security in the region. These events emphasize the need to strengthen and maintain a permanent system of well-organized surveys in areas that have recently received rains or been flooded, supported by a control capability to treat Desert Locust hopper bands and adult swarms efficiently in an environmentally safe and cost-effective manner.