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Vaccinations are an integral part of a flock health management program. They provide cheap insurance against diseases that commonly affect sheep and goats.

Probably, the only universally recommended vaccine for sheep and goats is CD-T. CD-T toxoid provides three-way protection against enterotoxemia (overeating disease) caused by Clostridium perfringins types C and D and tetanus (lockjaw) caused by Clostridium tetani. Seven and 8-way combination vaccines for additional clostridial diseases such as blackleg and malignant edema are available, but generally not necessary for small ruminants.